ICAM-1

ICAM1
PDBに登録されている構造
PDB	オルソログ検索: RCSB PDBe PDBj
PDBのIDコード一覧
	1D3E, 1D3I, 1D3L, 1IAM, 1IC1, 1MQ8, 1P53, 1Z7Z, 2OZ4, 3TCX
識別子
記号	ICAM1, BB2, CD54, P3.58, intercellular adhesion molecule 1
外部ID	OMIM: 147840 MGI: 96392 HomoloGene: 168 GeneCards: ICAM1
遺伝子の位置 (ヒト)
染色体	19番染色体 (ヒト)
終点	10,286,615 bp
遺伝子の位置 (マウス)
染色体	9番染色体 (マウス)
終点	20,940,113 bp
RNA発現パターン
	; ; ; ;
	さらなる参照発現データ
遺伝子オントロジー
分子機能	• virus receptor activity; • protein-containing complex binding; • integrin binding; • 血漿タンパク結合; • 膜貫通シグナル伝達受容体活性; • シグナル伝達受容体活性;
細胞の構成要素	• integral component of membrane; • 膜; • 焦点接着; • 細胞膜; • integral component of plasma membrane; • cell surface; • 免疫シナプス; • 脂質ラフト; • エキソソーム; • external side of plasma membrane; • 細胞外空間; • 細胞外マトリックス; • collagen-containing extracellular matrix;
生物学的プロセス	• leukocyte cell-cell adhesion; • response to ionizing radiation; • establishment of endothelial barrier; • negative regulation of endothelial cell apoptotic process; • 有機物への細胞応答; • heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules; • response to amino acid; • 低酸素症への反応; • positive regulation of actin filament polymerization; • 有機環状化合物への反応; • T cell antigen processing and presentation; • establishment of Sertoli cell barrier; • response to sulfur dioxide; • 銅イオンへの反応; • interferon-gamma-mediated signaling pathway; • positive regulation of nitric oxide biosynthetic process; • response to amphetamine; • cellular response to tumor necrosis factor; • regulation of leukocyte mediated cytotoxicity; • T cell activation via T cell receptor contact with antigen bound to MHC molecule on antigen presenting cell; • extracellular matrix organization; • acute inflammatory response to antigenic stimulus; • 聴覚; • cellular response to alkaloid; • response to gonadotropin; • positive regulation of cellular extravasation; • positive regulation of GTPase activity; • リポ多糖への反応; • regulation of cell adhesion; • 細胞接着; • cell adhesion mediated by integrin; • positive regulation of NF-kappaB transcription factor activity; • negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; • positive regulation of vasoconstriction; • cellular response to interleukin-1; • cellular response to nutrient levels; • negative regulation of calcium ion transport; • regulation of cell shape; • membrane to membrane docking; • positive regulation of peptidyl-tyrosine phosphorylation; • 卵胞発生; • regulation of immune response; • positive regulation of ERK1 and ERK2 cascade; • regulation of ruffle assembly; • ウイルス侵入; • response to ethanol; • viral process; • cellular response to lipopolysaccharide; • cellular response to hypoxia; • leukocyte migration; • cellular response to glucose stimulus; • response to insulin; • cellular response to interferon-gamma; • cellular response to interleukin-6; • デキサメタゾン刺激に対する細胞応答; • establishment of endothelial intestinal barrier; • positive regulation of leukocyte adhesion to vascular endothelial cell; • cellular response to leukemia inhibitory factor; • cell-cell adhesion; • サイトカイン媒介シグナル伝達経路; • T cell extravasation; • cellular response to amyloid-beta;
	出典:Amigo / QuickGO
オルソログ
	3383
	15894
	ENSG00000090339
	ENSMUSG00000037405
	P05362,K7EKL8
	P13597
	NM_000201
	NM_010493
	NP_000192
	NP_034623
	ウィキデータ
閲覧/編集ヒト	閲覧/編集マウス

ICAM-1または細胞間接着分子1（さいぼうかんせっちゃくぶんし1、英: intercellular adhesion molecule 1）は、ヒトではICAM1遺伝子にコードされるタンパク質である^[5]^[6]。CD54（cluster of differentiation 54）としても知られる。ICAM-1は細胞表面の糖タンパク質であり、一般的には血管内皮細胞と免疫系の細胞で発現している。CD11a（英語版）/CD18（英語版）、CD11b（英語版）/CD18型のインテグリンに結合し、またライノウイルスが呼吸上皮（英語版）に進入する際の受容体としても利用される^[7]。

^ ^a ^b ^c GRCh38: Ensembl release 89: ENSG00000090339 - Ensembl, May 2017
^ ^a ^b ^c GRCm38: Ensembl release 89: ENSMUSG00000037405 - Ensembl, May 2017
^ Human PubMed Reference:
^ Mouse PubMed Reference:
^ “Isolation and mapping of a polymorphic DNA sequence (pMCT108.2) on chromosome 18 [D18S24”]. Nucleic Acids Research 16 (9): 4188. (May 1988). doi:10.1093/nar/16.9.4188. PMC 336612. PMID 2453850.
^ “Chromosome mapping of cell membrane antigens expressed on activated B cells”. European Journal of Immunology 15 (1): 103–06. (Jan 1985). doi:10.1002/eji.1830150121. PMID 3871395.
^ “Entrez Gene: intercellular adhesion molecule 1”. 2021年5月4日閲覧。

[refGRCh38Ensembl-1] GRCh38: Ensembl release 89: ENSG00000090339 - Ensembl, May 2017

[refGRCm38Ensembl-2] GRCm38: Ensembl release 89: ENSMUSG00000037405 - Ensembl, May 2017

[3] Human PubMed Reference:

[4] Mouse PubMed Reference:

[pmid2453850-5] “Isolation and mapping of a polymorphic DNA sequence (pMCT108.2) on chromosome 18 [D18S24”]. Nucleic Acids Research 16 (9): 4188. (May 1988). doi:10.1093/nar/16.9.4188. PMC 336612. PMID 2453850.

[pmid3871395-6] “Chromosome mapping of cell membrane antigens expressed on activated B cells”. European Journal of Immunology 15 (1): 103–06. (Jan 1985). doi:10.1002/eji.1830150121. PMID 3871395.

[entrez-7] “Entrez Gene: intercellular adhesion molecule 1”. 2021年5月4日閲覧。

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